In an experimental environment with highly clean and precise requirements, the non-contact liquid workstation has demonstrated its unparalleled advantages. They can precisely control the size, shape and distribution position of droplets, ensuring that every operation reaches nanometer to picolitre level accuracy, which is suitable for the analysis of trace samples, the detection of highly sensitive biomarkers and the research of complex biological reaction systems. Of great significance.

1. Main features of non-contact liquid workstations 1. Non-contact operation: Non-contact liquid workstations distribute and transfer liquids through air pressure, sound waves, lasers or other non-contact mechanisms, thus avoiding the need for contact between the pipette head and the liquid. direct contact. 2. High precision: By avoiding physical friction and residual problems in contact operations, non-contact liquid workstations can achieve higher liquid distribution accuracy, which can usually reach the nanoliter (nL) or even picoliter (pL) level. 3. Low risk of contamination: Contactless operation significantly reduces the risk of cross-contamination because the liquid does not come into contact with the pipette tip or other tool surfaces, thereby reducing the spread of contaminants. 4. Automation and integration: Most non-contact liquid workstations have a high degree of automation and integration capabilities, and can be seamlessly connected with other laboratory equipment (such as testing instruments, sample storage systems, etc.) to realize the automation and integration of liquid handling processes. Intelligent. 5. Versatility: These workstations usually support a variety of liquid handling tasks, including but not limited to dispensing, mixing, dilution, transfer, and spotting, and are suitable for a variety of laboratory application scenarios.

2. Composition of non-contact liquid workstation 1. Control system (1) Hardware control: Responsible for the precise control and coordination of various components in the workstation, such as pressure systems, valves, pumps, etc., to ensure the accuracy and stability of non-contact operations . (2) Software interface: Provides a user-friendly graphical operation interface, allowing users to set and monitor experimental parameters, such as droplet size, distribution speed, target position, etc. The software may also have data logging, analysis and report generation capabilities. 2. Non-contact distribution system (1) Pressure or sound wave system: Use non-contact mechanisms such as air pressure and sound waves to generate droplets and distribute them to the target location. I-DOT technology, for example, is a pressure-based, non-contact dispensing system that applies customized pressure pulses through the top of a source plate to create droplets. (2) Micronozzles or microhole arrays: As outlets for droplet generation, these microstructures can precisely control the size and shape of droplets. 3. Liquid storage and delivery system (1) Liquid storage container: used to store liquid samples to be processed. These containers may need to have specific sealing and anti-pollution designs. (2) Transmission pipeline: connects the liquid storage container and the distribution system to ensure that the liquid can be transmitted to the distribution system smoothly and without pollution. 4. Target plate or receiving system (1) Target plate: used to receive droplets generated by the distribution system, which can be a 96-well plate, a 384-well plate or a microplate in other formats. (2) Positioning mechanism: Ensure that the target plate can be accurately and stably positioned under the distribution system to receive droplets. 5. Detection and calibration system (1) Imaging quality control camera: such as the TopView Camera module in the BioSpot Custom workstation, which is used for imaging quality control of the liquid dispensing process to ensure the accuracy and consistency of droplet distribution. (2) Droplet volume calibration module: such as the Smartdrop module, which quickly calibrates the droplet volume through an automatic calibration camera system to improve distribution accuracy. 6. Safety and protection system (1) Anti-contamination design: Reduce the risk of cross-contamination through non-contact operation and sealed liquid handling system. (2) Safety monitoring: It may include real-time monitoring and alarm functions of parameters such as temperature and pressure to ensure the safe operation of the workstation. 7. Other auxiliary components (1) Temperature control tray: used to control the temperature of liquid samples during processing to ensure the stability and repeatability of experimental conditions. (2) Suction tips and consumables: Although non-contact workstations reduce the use of suction tips, certain operations may still require the support of specific consumables.

3. Work flow of the non-contact liquid workstation 1. Liquid preparation: Place the liquid sample to be processed into the liquid storage container designated by the workstation. These containers may require specific sealing and contamination-proof designs. 2. Control system startup: The user sets experimental parameters, such as droplet size, distribution speed, target position, etc., through the control system of the workstation. The control system will start the corresponding hardware components based on these parameters. 3. Non-contact distribution: The distribution system uses non-contact mechanisms such as air pressure and sound waves to generate droplets according to the instructions of the control system. These droplets precisely control their size and shape through microstructures such as micronozzles or microhole arrays. The droplets are released and dispensed accurately into the target location, such as a 96-well plate, 384-well plate, or other microplate formats. 4. Detection and calibration: Some non-contact liquid workstations are also equipped with detection and calibration systems for real-time monitoring of the accuracy and consistency of droplet distribution. For example, the imaging quality control camera can be used to perform imaging quality control on the dispensing process, or the droplet volume calibration module can be used to quickly calibrate the droplet volume. 5. Data recording and analysis: Workstations usually have data recording functions and can automatically save key data during the experiment. Users can view and analyze these data through the software interface to verify and optimize experimental results.

With the rapid development of life sciences, genomics, drug discovery and other fields, non-contact liquid workstations are gradually becoming an indispensable and important tool in these cutting-edge scientific and technological fields. They not only simplify complex experimental procedures and improve experimental efficiency, but also open the door to the unknown world for scientists, helping them to move forward on the road to exploring the mysteries of life and overcoming disease problems.